Rizatriptan (RZT) is a potent anti migraine drug having agonist activity at the 5-hydroxytryptamine (5-HT) 1B and 5-HT 1D receptor used in treatment of migraine. In the present study, an attempt has been made to prepare fast dissolving film of RZT using eudragit E PO as a taste masking agent and film forming polymer. Various grades of HPMC 5 cp, 15 cp and 50 cp were selected as film former for immediate release of drug for this study. PEG 400 and glycerin were used as plasticizer. Film is prepared by solvent casting/evaporation technique and prepared film was evaluated for various parameters like thickness, folding endurance, disintegration test taste acceptability, tensile strength and drug release study. Mouth dissolving film containing RZT showed all the properties such as tensile strength, % percentage elongation, in-vitro disintegration and in-vitro dissolution characteristics within the limit without any type of imperfection. Drug release profile showed 100% within 10 min. The immediate drug release profile indicates that it could be successfully used to cure migraine attack without need of water for immediate release of drug. The mouth dissolving films was found superior in palatability and patient convenience than the tablets. It is suitable for pediatrics and elderly patients due to its convenience.
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